One major focus of cellular and molecular biology research is the identification and development of new therapeutics.
Scientists use high-throughput screening, computational modeling, and molecular assays to identify potential drug
candidates. These compounds are tested for their ability to interact with specific molecular targets, such as enzymes or
receptors, to modulate disease-related pathways. Once promising compounds are identified, researchers further analyze
their pharmacokinetics, toxicity, and efficacy in model organisms before advancing to clinical trials.
Traditional 2D cell cultures often fail to replicate human physiology, contributing to high drug candidate attrition
rates. To address this, the field is increasingly adopting 3D cell models and organoid systems that better mimic human
tissue complexity and disease states. High-throughput screening (HTS) platforms, enhanced by robotics and automated
liquid handling, now evaluate thousands of compounds daily, integrating advanced detection methods like LC-MS/MS and
phenotypic screening to assess efficacy and toxicity. Patravi Biotech leverages these innovations, employing scalable 3D
biology workflows and AI-driven target prioritization to accelerate lead compound identification while reducing
development costs.
The drug discovery pipeline requires rigorous validation of molecular targets, particularly for orphan receptors and
complex pathways identified through genomics and proteomics. Techniques such as cell-based chromatography and siRNA
screening enable rapid hit validation and mechanistic studies, even for natural product libraries. Patravi Biotech’s
expertise spans hit-to-lead optimization, leveraging computational ADMET profiling and transgenic animal models to
refine candidate selection. By integrating multi-omics data and adaptive clinical trial designs, we ensure seamless
transition from preclinical research to Phase I-IV trials, minimizing delays and maximizing therapeutic potential.
Our talented team at Patravi Biotechnology
delivers high quality services to ensure you meet your targeted results.